Infecções relacionadas à assistência à saúde causadas por Candida spp. em neonatos críticos: uma análise das superfícies ambientais
DOI:
https://doi.org/10.17058/reci.v14i4.19358Palavras-chave:
Infecções Fúngicas Invasivas, Infecção Hospitalar, Controle de Infecções, Saúde do LactenteResumo
Justificativa e Objetivos: infecções fúngicas invasivas acarretam elevada morbimortalidade em Unidades de Terapia Intensiva Neonatal (UTINs) e estão acompanhadas de um aumento de isolados resistentes, evidenciando o ambiente hospitalar como fonte primordial de contaminação. Este estudo identificou espécies de Candida em neonatos em uma UTIN brasileira, avaliou suas condições clínicas e laboratoriais e caracterizou os isolados. Métodos: isolados de Candidade recém-nascidos (RNs) e do ambiente foram identificados e analisados quanto à resistência antifúngica, fatores de virulência e relação molecular. Resultados: quatro RNs apresentaram candidíase invasiva, como C. albicans (2 RNs), C. glabrata (1 RN) e C. parapsilosis sensu stricto (1 RN). Todos RNs eram extremamente prematuros (<29 semanas) e utilizaram algum dispositivo invasivo. Dois isolados clínicos demonstraram resistência, um ao fluconazol (C. parapsilosissensu stricto) e o outro à micafungina (C. glabrata). Cinco isolados ambientais foram identificados como C. parapsilosissensu stricto, e um deles mostrou susceptibilidade dependente da dose ao fluconazol. O biofilme foi o único fator de virulência produzido pelos nove isolados. A análise molecular revelou alta similaridade entre um isolado ambiental e um clínico de C. parapsilosis sensu stricto. Conclusões: os resultados indicaram a presença de espécies de Candida em neonatos e no ambiente da UTIN, com algumas demonstrando resistência in vitro ao fluconazol e à micafungina. Todos isolados produziram biofilme. Foi observada uma notável similaridade genética entre alguns dos isolados ambientais e clínicos, sugerindo o ambiente como uma possível fonte de infecção.
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Copyright (c) 2025 Priscila Guerino Vilela, Isadora Caixeta da Silveira Ferreira, Ralciane de Paula Menezes, Mário Paulo Amante Penatti, Reginaldo dos Santos Pedroso, Denise Von Dolinger de Brito Röder
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