Consumo de antimicrobianos durante o período de pandemia de COVID-19 em macrorregiões específicas do Brasil
DOI:
https://doi.org/10.17058/reci.v14i2.18259Palavras-chave:
Acute respiratory infections., Antimicrobials., Brazil., COVID-19., Pharmacovigilance.Resumo
Justificativa e Objetivos: O objetivo principal foi analisar o consumo de antimicrobianos (ATMs) sujeito a retenção de receita e com indicações para tratamento de infecções respiratórias no Brasil de 2014 até 2021. Métodos: Trata-se de um estudo ecológico de desenho misto. Dados secundários foram obtidos do Sistema Nacional de Gerenciamento de Produtos Controlados (SNGPC). Dados foram apresentados conforme a seguinte equação: número total de consumo de ATMs por cada macrorregião do Brasil por ano ou trimestre/ número de residentes por cada macrorregião do Brasil por ano *1.000 habitantes. Dados anuais foram por Prais-Winsten, e dados trimestrais por regressão automática passo-a-passo. Resultados: Região Sul apresentou maiores taxas médias de consumo em comparação às demais macrorregiões. Para análise anual, a proporção de estabilidade, aumento e diminuição dos ATMs foi similar entre as macrorregiões. O trimestre registrou aumento no consumo de Amoxicilina, Amoxicilina+Clavulanato, Azitromicina e Cefalexina, juntas, nas regiões Sul, Sudeste e Norte. Conclusão: Nossos dados revelam um aumento no consumo de alguns ATMs durante o período de pandemia em macrorregiões específicas do Brasil, as cinco macrorregiões apresentaram padrões diferentes de consumo de ATMs.
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Referências
Abreu JAC de, Silva FBA. Uma “espada-de-dois-gumes”: bactérias & Covid-19 / A double-edged sword: bacterias & Covid-19. Brazilian J Dev 2021; 7: 53750–53769. DOI: 10.34117/bjdv.v7i5.30577
Mirzaei R, Goodarzi P, Asadi M, et al. Bacterial co-infections with SARS-CoV-2. IUBMB Life; 72. Epub ahead of print 2020. DOI: 10.1002/iub.2356.
Jin YH, Cai L, Cheng ZS, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Medical Research; 7. Epub ahead of print 2020. DOI: 10.1186/s40779-020-0233-6.
Miranda C, Silva V, Capita R, et al. Implications of antibiotics use during the COVID-19 pandemic: Present and future. J Antimicrob Chemother; 75. Epub ahead of print 2020. DOI: 10.1093/jac/dkaa350.
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet; 395. Epub ahead of print 2020. DOI: 10.1016/S0140-6736(20)30211-7.
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet; 395. Epub ahead of print 2020. DOI: 10.1016/S0140-6736(20)30183-5.
Heimfarth L, Serafini MR, Martins-Filho PR, et al. Drug repurposing and cytokine management in response to COVID-19: A review. International Immunopharmacology; 88. Epub ahead of print 2020. DOI: 10.1016/j.intimp.2020.106947.
Elshaboury RH, Monk MM, Bebell LM, et al. Remdesivir use and outcomes during the FDA COVID-19 emergency use authorization period. Ther Adv Infect Dis; 8. Epub ahead of print 2021. DOI: 10.1177/20499361211046669.
Costa KS, de Barros MBA, Francisco PMSB, et al. Use of medication and associated factors: A population-based study in Campinas, São Paulo State, Brazil. Cad Saude Publica; 27. Epub ahead of print 2011. DOI: 10.1590/s0102-311x2011000400004.
Khalatbari-Soltani S, Cumming RC, Delpierre C, et al. Importance of collecting data on socioeconomic determinants from the early stage of the COVID-19 outbreak onwards. Journal of Epidemiology and Community Health; 74. Epub ahead of print 2020. DOI: 10.1136/jech-2020-214297.
Castro MC, Kim S, Barberia L, et al. Spatiotemporal pattern of COVID-19 spread in Brazil. Science (80- ) 2021; 372: 821–826. DOI: 10.1126/science.abh1558
Ge H, Wang X, Yuan X, et al. The epidemiology and clinical information about COVID-19. European Journal of Clinical Microbiology and Infectious Diseases; 39. Epub ahead of print 2020. DOI: 10.1007/s10096-020-03874-z.
IBGE. Instituto Brasileiro de Geografia e Estatística - IBGE Cidades. Cidades. https://www.ibge.gov.br/
Kliemann BS, Levin AS, Moura ML, et al. Socioeconomic determinants of antibiotic consumption in the state of são paulo, brazil: The effect of restricting over-the-counter sales. PLoS One; 11. Epub ahead of print 2016. DOI: 10.1371/journal.pone.0167885.
Chua KP, Fischer MA, Linder JA. Appropriateness of outpatient antibiotic prescribing among privately insured US patients: ICD-10-CM based cross sectional study. BMJ; 364. Epub ahead of print 2019. DOI: 10.1136/bmj.k5092.
Olesen SW, Barnett ML, Macfadden DR, et al. Trends in outpatient antibiotic use and prescribing practice among US older adults, 2011-15: Observational study. BMJ; 362. Epub ahead of print 2018. DOI: 10.1136/bmj.k3155.
Martins AFL. Desigualdades Regionais e Desenvolvimento entre as Cinco Macrorregiões do Brasil. Universidade de Montes Clarosvancouver, 2015. https://www.posgraduacao.unimontes.br/uploads/sites/20/2019/05/Andr%C3%A9-Martins-PPGDS.pdf
Thibodeau KP, Viera AJ. Atypical Pathogens and Challenges in Community-Acquired Pneumonia. American Family Physician; 69. PMID: 15086042 https://pubmed.ncbi.nlm.nih.gov/15086042/
De Francesco MA, Poiesi C, Gargiulo F, et al. Co-infection of chlamydia pneumoniae and mycoplasma pneumoniae with SARS-CoV-2 is associated with more severe features. Journal of Infection; 82. Epub ahead of print 2021. DOI: 10.1016/j.jinf.2021.01.009.
Mitidieri TL, Pimentel VP, Braga C de A, et al. Há espaços competitivos para a indústria farmoquímica brasileira? Reflexões e propostas para políticas públicas. BNDES Setorial; 41. http://web.bndes.gov.br/bib/jspui/handle/1408/4286
Buehrle DJ, Wagener MM, Nguyen MH, et al. Trends in Outpatient Antibiotic Prescriptions in the United States during the COVID-19 Pandemic in 2020. JAMA Netw Open; 4. Epub ahead of print 2021. DOI: 10.1001/jamanetworkopen.2021.26114.
Silva TM, Estrela M, Gomes ER, et al. The impact of the covid‐19 pandemic on antibiotic prescribing trends in outpatient care: A nationwide, quasi‐experimental approach. Antibiotics; 10. Epub ahead of print 2021. DOI: 10.3390/antibiotics10091040.
Gillies MB, Burgner DP, Ivancic L, et al. Changes in antibiotic prescribing following COVID-19 restrictions: Lessons for post-pandemic antibiotic stewardship. Br J Clin Pharmacol; 88. Epub ahead of print 2022. DOI: 10.1111/bcp.15000.
CFM. CONSELHO FEDERAL DE MEDICINA. RESOLUÇÃO CFM no2.299. Publicada no Diário Of da União 26 outubro 2021(2021). https://sistemas.cfm.org.br/normas/arquivos/resolucoes/BR/2021/2299_2021.pdf
Peñalva G, Benavente RS, Pérez-Moreno MA, et al. Effect of the coronavirus disease 2019 pandemic on antibiotic use in primary care. Clinical Microbiology and Infection; 27. Epub ahead of print 2021. DOI: 10.1016/j.cmi.2021.01.021.
Van de Pol AC, Boeijen JA, Venekamp RP, et al. Impact of the covid-19 pandemic on antibiotic prescribing for common infections in the netherlands: A primary care-based observational cohort study. Antibiotics; 10. Epub ahead of print 2021. DOI: 10.3390/antibiotics10020196.
Zhu N, Aylin P, Rawson T, et al. Investigating the impact of COVID-19 on primary care antibiotic prescribing in North West London across two epidemic waves. Clin Microbiol Infect; 27. Epub ahead of print 2021. DOI: 10.1016/j.cmi.2021.02.007.
Caetano MC, Campos MR, Emmerick ICM, et al. Consumo de antimicrobianos nas farmácias e drogarias privadas brasileiras à luz do PAN-BR e da pandemia de COVID-19 / Antimicrobial consumption in Brazilian private pharmacies and drugstores considering the PAN-BR and COVID-19 pandemic. Brazilian J Dev; 8. Epub ahead of print 2022. DOI: 10.34117/bjdv8n1-043.
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