Evaluation of antifungal, antimycobacterial and larvicide activity of the Duroia macrophylla and D. saccifera

Ana Júlia Reis, Lillian Lucas Carrion, Katiane Rodrigues, Juliana Montelli Fenalti, Tais Mata-Santos, Carlos James Scaini, Daiane Martins, Denny William de Oliveira Mesquita, Adriana Spirotto Stein Mesquita, Cecília Verônica Nunez, Pedro Eduardo Almeida da Silva, Daniela Fernandes Ramos

Abstract


Bachground and objective: The wide Amazonian biodiversity has been identified as a source of natural product candidates to various pharmacological activities, particularly in combating infectious diseases. Some species, such as the genus Duroia, belonging to the Rubiaceae family, has been characterized by the production of secondary metabolites with important biological properties, but there are few studies with species of this genus. Thus, the objective of this study was to evaluate the antimycobacterial, antifungal and antiparasitic activity of D. macrophylla and D. saccifera extracts by determining the minimum inhibitory concentration and minimum larvicide concentration. Methods: Were collected plant materials of the D. macrophylla and D. saccifera in Forest Reserve A. Ducke in Manaus AM, from which were prepared dichloromethane, methanol and aqueous extracts and determined the minimum inhibitory concentration and larvicidal concentration. Results: With regard to D. saccifera¸ extracts the dichloromethane extract of the branches was the most active against the fungal species and mycobacterial strains evaluated. On the other hand, the methanol and dichloromethane extract of the D. macrophylla leaves, were most active against Candida sp. and Mycobacterium tuberculosis, respectively, but none of the six evaluated extracts showed antiparasitic activity against Toxocara canis. Conclusion: These results demonstrate the antimicrobial properties of these Amazonian plants for the development of new therapies in the treatment of infectious diseases such as tuberculosis and candidiasis.



DOI: http://dx.doi.org/10.17058/reci.v1i1.8188



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