Evaluation of antifungal, antimycobacterial and larvicide activity of the Duroia macrophylla and D. saccifera

Authors

  • Ana Júlia Reis Universidade Federal do Rio Grande (FURG) – Faculdade de Medicina – Área Interdisciplinar em Ciências Biomédicas – Núcleo de Pesquisas em Microbiologia Médica, Rio Grande, Rio Grande do Sul, Brasil
  • Lillian Lucas Carrion Universidade Federal do Rio Grande (FURG) – Faculdade de Medicina – Área Interdisciplinar em Ciências Biomédicas – Núcleo de Pesquisas em Microbiologia Médica, Rio Grande, Rio Grande do Sul, Brasil.
  • Katiane Rodrigues Universidade Federal do Rio Grande (FURG) – Faculdade de Medicina – Área Interdisciplinar em Ciências Biomédicas – Núcleo de Pesquisas em Microbiologia Médica, Rio Grande, Rio Grande do Sul, Brasil.
  • Juliana Montelli Fenalti Universidade Federal do Rio Grande (FURG) – Faculdade de Medicina – Área Interdisciplinar em Ciências Biomédicas – Laboratório de Parasitologia, Rio Grande, Rio Grande do Sul, Brasil.
  • Tais Mata-Santos Universidade Federal do Rio Grande, Rio Grande, RS, Brasil.
  • Carlos James Scaini Universidade Federal do Rio Grande (FURG) – Faculdade de Medicina – Área Interdisciplinar em Ciências Biomédicas – Laboratório de Parasitologia, Rio Grande, Rio Grande do Sul, Brasil.
  • Daiane Martins Instituto Nacional de Pesquisas da Amazônia (INPA), Laboratório de Bioprospecção e Biotecnologia, Manaus, Amazonas, Brasil.
  • Denny William de Oliveira Mesquita Instituto Nacional de Pesquisas da Amazônia (INPA), Laboratório de Bioprospecção e Biotecnologia, Manaus, Amazonas, Brasil.
  • Adriana Spirotto Stein Mesquita Instituto Nacional de Pesquisas da Amazônia (INPA), Laboratório de Bioprospecção e Biotecnologia, Manaus, Amazonas, Brasil.
  • Cecília Verônica Nunez Instituto Nacional de Pesquisas da Amazônia (INPA), Laboratório de Bioprospecção e Biotecnologia, Manaus, Amazonas, Brasil
  • Pedro Eduardo Almeida da Silva Universidade Federal do Rio Grande (FURG) – Faculdade de Medicina – Área Interdisciplinar em Ciências Biomédicas – Núcleo de Pesquisas em Microbiologia Médica, Rio Grande, Rio Grande do Sul, Brasil.
  • Daniela Fernandes Ramos Universidade Federal do Rio Grande (FURG) – Faculdade de Medicina – Área Interdisciplinar em Ciências Biomédicas – Núcleo de Pesquisas em Microbiologia Médica, Rio Grande, Rio Grande do Sul, Brasil

DOI:

https://doi.org/10.17058/reci.v1i1.8188

Abstract

Bachground and objective: The wide Amazonian biodiversity has been identified as a source of natural product candidates to various pharmacological activities, particularly in combating infectious diseases. Some species, such as the genus Duroia, belonging to the Rubiaceae family, has been characterized by the production of secondary metabolites with important biological properties, but there are few studies with species of this genus. Thus, the objective of this study was to evaluate the antimycobacterial, antifungal and antiparasitic activity of D. macrophylla and D. saccifera extracts by determining the minimum inhibitory concentration and minimum larvicide concentration. Methods: Were collected plant materials of the D. macrophylla and D. saccifera in Forest Reserve A. Ducke in Manaus AM, from which were prepared dichloromethane, methanol and aqueous extracts and determined the minimum inhibitory concentration and larvicidal concentration. Results: With regard to D. saccifera¸ extracts the dichloromethane extract of the branches was the most active against the fungal species and mycobacterial strains evaluated. On the other hand, the methanol and dichloromethane extract of the D. macrophylla leaves, were most active against Candida sp. and Mycobacterium tuberculosis, respectively, but none of the six evaluated extracts showed antiparasitic activity against Toxocara canis. Conclusion: These results demonstrate the antimicrobial properties of these Amazonian plants for the development of new therapies in the treatment of infectious diseases such as tuberculosis and candidiasis.

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Published

2016-10-05

How to Cite

Reis, A. J., Lucas Carrion, L., Rodrigues, K., Montelli Fenalti, J., Mata-Santos, T., Scaini, C. J., Martins, D., de Oliveira Mesquita, D. W., Spirotto Stein Mesquita, A., Nunez, C. V., Almeida da Silva, P. E., & Fernandes Ramos, D. (2016). Evaluation of antifungal, antimycobacterial and larvicide activity of the Duroia macrophylla and D. saccifera. Revista De Epidemiologia E Controle De Infecção, 1(1), 108-124. https://doi.org/10.17058/reci.v1i1.8188

Issue

v. 6 (2016): SUPLEMENTO - II Congresso Brasileiro Interdisciplinar de Promoção da Saúde

Section

ORIGINAL ARTICLE

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