Bacteremia caused by Staphylococcus aureus: a fifteen-year analysis of antimicrobial susceptibility in a tertiary hospital in Brazil

Authors

  • Felipe Crepaldi Duarte Programa de Mestrado em Fisiopatologia Clínica e Laboratorial. Departamento de Patologia, Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Estadual de Londrina
  • Tiago Danelli Programa de Mestrado em Fisiopatologia Clínica e Laboratorial. Departamento de Patologia, Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Estadual de Londrina
  • Maria Alice Galvão Ribeiro Programa de Mestrado em Microbiologia. Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina.
  • Luis Felipe Perugini Bolsista de Iniciação Científica da Fundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico. Curso de Farmácia. Centro de Ciências da Saúde. Universidade Estadual de Londrina.
  • Eliana Carolina Vespero Laboratório de Microbiologia Clínica do Hospital Universitário de Londrina. Docente do Departamento de Patologia, Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Estadual de Londrina
  • Floristher Elaine Carrara-Marroni Laboratório de Microbiologia Clínica do Hospital Universitário de Londrina. Docente do Departamento de Patologia, Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Estadual de Londrina
  • Marsileni Pelisson Laboratório de Microbiologia Clínica do Hospital Universitário de Londrina. Docente do Departamento de Patologia, Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Estadual de Londrina
  • Lucy Megumi Yamauchi Laboratório de Biologia Molecular de Microrganismos. Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina.
  • Sueli Fumie Yamada-Ogatta Laboratório de Biologia Molecular de Microrganismos. Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina.
  • Marcia Regina Eches Perugini Laboratório de Microbiologia Clínica do Hospital Universitário de Londrina. Docente do Departamento de Patologia, Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Estadual de Londrina

DOI:

https://doi.org/10.17058/reci.v8i3.11245

Abstract

Background and Objective: Bloodstream infections caused by Staphylococcus aureus are a major cause of morbidity and mortality worldwide. Treatment of S. aureus infections is complex, in part, due to the high prevalence of antimicrobial resistance. Understanding the epidemiology and resistance patterns of this microorganism is a critical point for the proper empirical prescription of antimicrobials. Thus, this study aimed to evaluate the evolution of antimicrobial resistance of S. aureus in a period of fifteen years. Methods: Antimicrobial susceptibility profiles was determined for cefoxitin (30μg), penicillin (10 U), erythromycin (15 μg), clindamycin (2 μg), gentamycin (10 μg),ciprofloxacin (5μg), sulfamethoxazole-trimethoprim (23.75/1.25 μg), rifampicin (5 μg), and tetracycline (30μg) in 720 S. aureus isolated from blood cultures in a tertiary hospital in southern Brazil were analyzed. Sensiblity values was determined according to Clinical Laboratory Standards Institute (CLSI, 2018).The data were obtained from the AGTA Healthcare Information System, LABHOS ® module. Results: The mean frequency of methicillin-resistant S. aureus was 43.74%. Except for penicillin, there was a significant variation of resistance for all antimicrobials in the period evaluated (ρ<0.001). Ciprofloxacin (51.14%), erythromycin (44.99%) and clindamycin (39.85%) had the highest rates of resistance, with tendency to increase. Surprisingly, gentamicina (4%) and sulfamethoxazole-trimethoprim (4%) showed a significant percentage decrease in resistance. For vancomycin, from 2010 to 2015, it was observed an increase in minimum inhibitory concentrations. Conclusion: Although the resistance rate increased in the fifteen years for most antimicrobials, for sulfamethoxazole-trimethoprim and gentamicin a significant reduction occurred, indicating a possible clonal change. This study also evidenced the emergence of S. aureus with intermediate resistance to vancomycin phenotype.

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Published

2018-07-01

How to Cite

Duarte, F. C., Danelli, T., Ribeiro, M. A. G., Perugini, L. F., Vespero, E. C., Carrara-Marroni, F. E., Pelisson, M., Yamauchi, L. M., Yamada-Ogatta, S. F., & Eches Perugini, M. R. (2018). Bacteremia caused by Staphylococcus aureus: a fifteen-year analysis of antimicrobial susceptibility in a tertiary hospital in Brazil. Revista De Epidemiologia E Controle De Infecção, 8(3), 232-238. https://doi.org/10.17058/reci.v8i3.11245

Issue

Vol. 8 No. 3 (2018)

Section

ORIGINAL ARTICLE

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