Association between severity score, inflammatory levels and DNA damage in intensive care patients

Authors

DOI:

https://doi.org/10.17058/jeic.v10i3.14110

Keywords:

Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage.

Abstract

Background and Objectives: The Intensive Care Unit (ICU) is responsible for the treatment of critical patients and monitoring it continuously can improve the quality of care provided. This study aims to associate the Simplified Acute Physiology Score (SAPS 3) with inflammatory levels and genomic damage in patients admitted to the ICU of a hospital in Vale do Taquari, Rio Grande do Sul, Brazil. Methods: This is a cross-sectional study conducted with 22 patients from an adult ICU,between January and June 2016. The SAPS 3 was scored by the medical staff at the admission of patients and blood samples were obtained after 24 and 72 hours of hospitalization for C-Reactive Protein (CRP) dosing and DNA damage. Results: The SAPS 3 score was not associated with 24-and 72-hours CRP. However, the SAPS 3 score was significantly associated with the index and frequency of DNA damage, only after 72 hours of hospitalization. Conclusion: The severity score was not associated with CRP levels, but with DNA damage only after 72 hours of admission. Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage.

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Author Biography

Patrícia Molz, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Brasil

Nutricionista e mestre  em Promoção da Saúde pela Universidade de Santa Cruz do Sul (UNISC) e doutoranda pela Pontifícia Universidade Católica do Rio Grande do Sul, (PUCRS)

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Published

2020-07-07

How to Cite

Mattje, A. V., Molz, P., de Oliveira, C. F., Schlickmann, D. da S., Renner, J. D. P., Kraether Neto, L., Prá, D., & Franke, S. I. R. (2020). Association between severity score, inflammatory levels and DNA damage in intensive care patients. Revista De Epidemiologia E Controle De Infecção, 10(3). https://doi.org/10.17058/jeic.v10i3.14110

Issue

Vol. 10 No. 3 (2020)

Section

ORIGINAL ARTICLE

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