Rhodotorula fungemia in a patient with acute lymphoblastic leukemia

Authors

DOI:

https://doi.org/10.17058/reci.v12i1.16325

Keywords:

Rhodotorula, Amphotericin, Acute Lymphoblastic Leukemia

Abstract

Objectives: Rhodotorula is an environmental yeast that belongs to Basidiomycota Phylum. Rhodotorula species are ubiquitous in nature, can be found in soil and freshwater. Immunocompromised patients can develop Rhodotorulosis due to wide-ranging exposure to Rhodotorula in the hospital environment. Case Discussion: The patient was a 3-year-old male with a diagnosis of Pro B-Acute Lymphoblastic Leukemia (ALL). He was admitted to the hospital with complaints of malaise, fatigue, weight loss, and diarrhea between courses of chemotherapy. Rhodotorula was isolated from the patient’s blood culture obtained during the elevation of temperature. After 14 days of amphotericin B treatment, clinical situation of the patient was improved and he was discharged. Conclusion: Rhodotorula spp. as a rare yet emerging pathogen, often presents as fever of unknown etiology resistant to antibacterial treatment and can be associated with fungemia and other severe complications.   

Downloads

Download data is not yet available.

Author Biographies

Mehmet Erinmez, Gaziantep University, Faculty of Medicine, Department of Medical Microbiology

Department of Medical Microbiology, MD

Yasemin Zer, Gaziantep University, Faculty of Medicine, Department of Medical Microbiology

Department of Medical Microbiology, Professor

Ayşe Büyüktaş Manay, Gaziantep University, Faculty of Medicine, Department of Medical Microbiology

Department of Medical Microbiology, Professor, MSc

References

Tournas VH, Katsoudas E, Miracco EJ. Moulds, yeasts and aerobic plate counts in ginseng supplements. Int J Food Microbiol. 2006; 108:178–81. https://doi.org/10.1016/j.ijfoodmicro.2005.11.009

Hagan ME, Klotz SA, Bartholomew W, et al. A pseudoepidemic of Rhodotorula rubra: a marker for microbial contamination of the bronchoscope. Infect Control Hosp Epidemiol. 1995; vol. 16[12]:727– 728. https://doi.org/10.1086/647048

Potenza L, Chitasombat MN, Klimko N, et al. Rhodotorula infection in haematological patient: Risk factors and outcome. Mycoses. 2019 Mar;62(3):223-229. https://doi.org/10.1111/myc.12875

Miceli MH, Díaz JA, Lee SA. Emerging opportunistic yeast infections. Lancet Infect Dis. 2011; 11[2]:142–51. https://doi.org/10.1016/S1473-3099(10)70218-8

Lunardi LW, Aquino VR, Zimerman RA, et al. Epidemiology and outcome of Rhodotorula fungemia in a tertiary care hospital. Clin Infect Dis. 2006; 43[6]:e60-3. https://doi.org/10.1086/507036

Tuon FF, Costa SF. Rhodotorula infection. A systematic review of 128 cases from literature. Rev Iberoam Micol. 2008; 25(3):135-40. https://doi.org/10.1016/s1130-1406(08)70032-9

Ioannou P, Vamvoukaki R, Samonis G. Rhodotorula species infections in humans: A systematic review. Mycoses. 2019 Feb;62(2):90-100. http://dx.doi.org/10.1111/myc.12856

Strati F, Di Paola M, Stefanini I, et al. Age and Gender Affect the Composition of Fungal Population of the Human Gastrointestinal Tract. Front Microbiol. 2016; 7:1227. https://doi.org/10.3389/fmicb.2016.01227

Wirth F, Goldani LZ. Epidemiology of Rhodotorula: an emerging pathogen. Interdiscip Perspect Infect Dis. 2012; 2012:465717. https://doi.org/10.1155/2012/465717

Gharaghani M, Taghipour S, Zarei Mahmoudabadi A. Molecular identification, biofilm formation and antifungal susceptibility of Rhodotorula spp. Mol Biol Rep. 2020 Nov;47(11):8903-8909. doi: 10.1007/s11033-020-05942-1. https://doi.org/10.1007/s11033-020-05942-1

Downloads

Published

2022-05-24

How to Cite

Erinmez, M., Zer, Y., & Büyüktaş Manay, A. (2022). Rhodotorula fungemia in a patient with acute lymphoblastic leukemia. Revista De Epidemiologia E Controle De Infecção, 12(1). https://doi.org/10.17058/reci.v12i1.16325

Issue

Section

EXPERIENCE REPORT