Clinical-epidemiological characteristics of pregnant women with HIV/syphilis coinfection: an integrative review
DOI:
https://doi.org/10.17058/reci.v13i4.18230Keywords:
HIV, Syphilis, Pregnant Women, CoinfectionAbstract
Background and Objectives: HIV/syphilis coinfection is an important problem to be considered during pregnancy due to the various negative outcomes such as abortion, stillbirth, prematurity and congenital infections. The study is justified by the need to identify scientific evidence of clinical-epidemiological characteristics and vulnerabilities related to infections, factors that influence the prevalence, and if there are related health problems. The objective was to synthesize scientific evidence about sociodemographic characteristics and clinical manifestations of associated cases of syphilis and HIV. Content: this is an integrative literature review, searching the PubMed, MEDLINE, CINAHL, LILACS, BDENF and MedCarib databases, using the descriptors “HIV”, “Syphilis”, “Epidemiology”, “Coinfection” and “Pregnant woman”, combined by Boolean operators “AND” and “OR”, guided by the question: what is the scientific evidence related to the clinical-epidemiological characteristics of pregnant women co-infected with HIV/syphilis? It was held from June to September 2022, including articles published in the last eight years. Nine primary articles published between 2015 and 2020 were selected. The association of infections was present in pregnant women of young adult age, non-white race/color, married, low level of education, housewives, residents of urban areas and belonging to more economically disadvantaged social classes. Conclusion: the study highlighted the importance of improving prenatal care, with the aim of reducing the risks of vertical transmission of these diseases, especially with the implementation of public policies aimed at the clinical management of co-infected pregnant women, the allocation of resources and the development of specific intervention protocols.
Downloads
References
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Protocolo Clínico e Diretrizes Terapêuticas para Prevenção da Transmissão Vertical de HIV, Sífilis e Hepatites Virais. Brasília: Ministério da Saúde; 2022.
Mora Y, Mago H, Díaz I. Coinfección VIH-Sífilis en pacientes con diagnóstico reciente de infección por virus de inmunodeficiencia humana, octubre 2018 - mayo 2019, Unidad de Infectología. Ciudad Hospitalaria Dr. Enrique Tejera. Bol Venez Infectol. 2019;30(2):116-21.
Vasconcelos MSB, Silva DSB, Peixoto IB. Coinfecção entre HIV e Sífilis: principais complicações clínicas e interferências no diagnóstico laboratorial. RBAC. 2021;53(1):15-20. http://dx.doi.org/10.21877/2448-3877.202102057
Soares BGMR, Marinho MAD, Linhares MI, et al. Perfil das notificações de casos de Sífilis gestacional e Sífilis congênita. Sanare. 2017;16(02):51-9. https://doi.org/10.36925/sanare.v16i2.1178
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Boletim Epidemiológico – Sífilis. Brasília: Ministério da Saúde; 2021.
Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Boletim Epidemiológico –HIV/Aids. Brasília: Ministério da Saúde; 2021.
Macêdo VC, Romaguera LMD, Ramalho MOA, et al. Sífilis na gestação: barreiras na assistência pré-natal para o controle da transmissão vertical. Cad Saúde Col. 2020;28(4):518-28. https://doi.org/10.1590/1414-462X202028040395
Luppi CG, Gomes SEC, Silva RJC, et al. Fatores associados à coinfecção por HIV em casos de Sífilis adquirida notificados em um Centro de Referência de Doenças Sexualmente Transmissíveis e Aids no município de São Paulo, 2014. Epidemiologia e Serviços de Saúde. 2018;27(1):1-12. https://doi.org/10.5123/S1679-49742018000100008
Mendes KDS, Silveira RCCP, Galvão CM. Use of the bibliographic reference manager in the selection of primary studies in integrative reviews. Texto & Contexto Enferm [Internet]. 2019 [citado 2022 nov 13];(28): e20170204. https://doi.org/10.1590/1980-265X-TCE-2017-0204
Aromataris E, Munn Z (Editors). JBI Manual for Evidence Synthesis. Adelaide: Joanna Briggs Institute; 2020. https://doi.org/10.46658/JBIMES-20-01
Ministério da Saúde (BR). Portaria nº77, de 12 de janeiro de 2012. Dispõe sobre a realização de testes rápidos, na atenção básica, para a detecção de HIV e Sífilis, assim como testes rápidos para outros agravos, no âmbito da atenção pré-natal para gestantes e suas parcerias sexuais. Diário Oficial da República Federativa do Brasil, Brasília (DF), 2012.
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71
Ursi ES. Prevenção de lesões de pele no perioperatório: revisão integrativa da literatura [dissertação]. 2005. 130 F. Ribeirão Preto (SP): Universidade de São Paulo; 2005.
Machotka Z, Kumar S, Perraton LG. A systematic review of the literature on the effectiveness of exercise therapy for groin pain in athletes. Sports Med Arthrosc Rehabil Ther Technol. 2009;1(1):1-10. http://dx.doi.org/10.1186/1758-2555-1-5
Moura AA, Mello MJG, Correia JB. Prevalence of syphilis, human immunodeficiency virus, hepatitis B virus, and human T-lymphotropic virus infections and coinfections during prenatal screening in an urban Northeastern Brazilian population. Int J Infect Dis. 2015;39:10-15. https://doi.org/10.1016/j.ijid.2015.07.022
Kengne-Nde C, Anoubissi JD, Loni-Ekali G, et al. Highlighting a population-based re-emergence of Syphilis infection and assessing associated risk factors among pregnant women in Cameroon: Evidence from the 2009, 2012 and 2017 national sentinel surveillance surveys of HIV and syphilis. PLoS One. 2020;15(11):e0241999. http://dx.doi.org/10.1371/journal.pone.0241999
Acosta LMW, Gonçalves TR, Barcellos NT. Coinfecção HIV/Sífilis na gestação e transmissão vertical do HIV: um estudo a partir de dados da vigilância epidemiológica. Rev Panam Salud Publica. 2016;40(6):435- 42.
Biadgo B, Hassen A, Getaneh M, et al. Syphilis and human immunodeficiency virus infections among pregnant women attending antenatal care clinic of Gondar family guidance association, Northwest Ethiopia: implication for prevention of mother to child transmission. Reprod Health. 2019;16(1):27-34. http://dx.doi.org/10.1186/s12978-019-0691-z
Araújo EC, Monte PCB, Haber ANCA. Avaliação do pré-natal quanto à detecção de Sífilis e HIV em gestantes atendidas em uma área rural do estado do Pará, Brasil. Rev Pan-Amaz Saude. 2018;9(1):33-9. http://dx.doi.org/10.5123/s2176-62232018000100005
Davey DLJ, Nyemba DC, Gomba Y, et al. Prevalence and correlates of sexually transmitted infections in pregnancy in HIVinfected and- uninfected women in Cape Town, South Africa. PLoS ONE. 2019;14(7): e0218349. https://doi.org/10.1371/journal.pone.0218349
Dionne-Odom J, Khan MJ, Jauk VC, et al. HIV status and other risk factors for prevalent and incident sexually transmitted infection during pregnancy (2000-2014). Infect Dis Obstet Gynecol. 2019;2019:6584101. https://doi.org/10.1155/2019/6584101
Niama, RF, Bongolo NCL, Kombo ESB, et al. Syphilis and HIV infections among pregnant women attending antenatal clinics in Republic of Congo. Pan Afr Med J. 2017;28(8)1-8. https://doi.org/10.11604/pamj.2017.28.8.13097
Endris M, Deressa T, Belyhun Y, et al. Seroprevalence of syphilis and human immunodeficiency virus infections among pregnant women who attend the University of Gondar teaching hospital, Northwest Ethiopia: a cross sectional study. BMC Infect Dis. 2015;15:111-7. https://doi.org/10.1186/s12879-015-0848-5
Yeganeh N, Watts HD, Camarca M, et al. Syphilis in HIV-Infected Mothers and Infants: Results from the NICHD/HPTN 040 Study. Pediatr Infect Dis J. 2016;34(3):1-13. http://dx.doi.org/10.1097/INF.0000000000000578
Spindola T, Santana RSC, Antunes RF,et al. A prevenção das infecções sexualmente transmissíveis nos roteiros sexuais de jovens: diferenças segundo o gênero. Cien Saude Colet. 2021;26(7):2683-92. https://doi.org/10.1590/1413-81232021267.08282021
Canani RG, Souza MCF, Bellinati NVC, et al. Prevalência de Sífilis gestacional e fatores associados: um panorama da serra catarinense. Revista Recien. 2022;12(37):323-33. https://doi.org/10.24276/rrecien2022.12.37.323-333
Kinikar A, Gupte N, Bhat J, et al. Maternal syphilis: an independent risk factor for mother to infant human immunodeficiency virus transmission. Sex Transm Dis. 2017;44(6):371-375. https://doi.org/10.1097/OLQ.0000000000000622
Mutagoma M, Balisanga H, Remera E, et al. Ten-year trends of syphilis in sero-surveillance of pregnant women in Rwanda and correlates of syphilis-HIV co-infection. Int J STD AIDS. 2017;28(1):45-53. https://doi.org/10.1177/0956462415624058
Anoubissi JD, Gabriel EL, Kengne Nde C, et al. Factors associated with risk of HIV-infection among pregnant women in Cameroon: evidence from the 2016 national sentinel surveillance survey of HIV and syphilis. PLoS ONE. 2019;14(4):e0208963. http://dx.doi.org/10.1371/journal.pone.0208963
Batistão FV, Silva HCG, Schuelter-Trevisol F. Syphilis, HIV and hepatitis B and C serological screening among parturient admitted in the obstetrics center of a hospital in Southern Brazil, 2014–2016. J bras Doenças Sex Transm. 2017;29(3):96-100. https://doi.org/10.5533/DST-2177-8264-201729305
Leopoldino MA, Chaves EBM, Silva CLO, et al. Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil. Clin Biomed Res. 2017;37(4)269-74. http://dx.doi.org/10.4322/2357-9730.73975
Monteiro RS, Côrtes PPR. A relação entre Sífilis congênita e o tratamento do parceiro da gestante: um estudo epidemiológico. Revista Pró-UniverSUS. 2019;20(2):13-7. https://doi.org/10.21727/rpu.v10i2.1934
Baptista FH, Rocha KBB, Martinelli JL, et al. Prevalência e fatores associados ao consumo de álcool durante a gravidez. Rev Bras Saude Mater Infant. 2017;17(2):271-9. https://doi.org/10.1590/1806-93042017000200004
Carvalho NS, Berti CCV, Rauen J, et al. Human Immunodeficiency Virus infection associated with crack cocaine use: the impact on perinatal transmission among 890 pregnancies in Brazil. DST J Bras Doenças Sex Transm. 2021;33:1-7. https://doi.org/10.5327/DST-2177-8264-20213336
U.S. Department of Health and Human Services; Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2018. https://doi.org/10.15620/cdc.79370
Janier M, Unemo M, Dupin N, et al. 2020 European guideline on the management of syphilis. Journal of the European Academy of Dermatology and Venereology. 2021;35(3):574-88. https://doi.org/10.1111/jdv.16946
Solino MSS, Santos NSS, Almeida MCS, et al. Challenges of nurses in nursing care for users diagnosed with syphilis. Braz J Hea Rev. 2020;3(5):13917-30. https://doi.org/10.34119/bjhrv3n5-203
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Janaina Miranda Bezerra, Sannaya da Silva Ferreira, Joênnya Karine Mendes Carvalho, Ana Karoline Lima Nascimento, Adriana Gomes Nogueira Ferreira, Marcelino Santos Neto
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author must state that the paper is original (has not been published previously), not infringing any copyright or other ownership right involving third parties. Once the paper is submitted, the Journal reserves the right to make normative changes, such as spelling and grammar, in order to maintain the language standard, but respecting the author’s style. The published papers become ownership of RECI, considering that all the opinions expressed by the authors are their responsibility. Because we are an open access journal, we allow free use of articles in educational and scientific applications provided the source is cited under the Creative Commons CC-BY license.
