Clinical, epidemiological, and laboratorial profile of arboviruses of suspected cases during Brazilian Zika virus emergence
DOI:
https://doi.org/10.17058/reci.v14i3.19176Keywords:
Arboviruses, Epidemiology, Molecular Diagnostic, SerologyAbstract
Background and Objectives: Arboviruses are public health issues worldwide related to severe human health impairment. These viruses cause similar acute febrile syndromes, challenging differential diagnosis and adequate notification. The work aimed to describe the epidemiological and laboratorial profile of arboviruses of suspected cases reported in southeastern Mato Grosso (MT) during the Zika virus emergence in Brazil. Methods: Epidemiological and clinical features of arboviruses were analyzed in a descriptive and retrospective study. Serum samples were assessed by real-time reverse transcriptase polymerase chain reaction for detection of Zika, Dengue and Chikungunya, and by immunoassay for detection of IgM and IgG against Zika. Results: Of 197 patients, 63% were female, eight were pregnant. Mean age was 32 years, with 44% between 19-59 years; 28% were white, 34% had educational instruction, and 58.9% were urban residents. About 61% of cases occurred during rainy seasons, with 12.1% in three regions of the study area. Musculoskeletal disorders were the main complaints (22.8%), followed by fever (13.7%), rash and petechiae (12.6%), headache (11.7%), itching (10%), ophthalmological manifestations (6.1%) and gastrointestinal manifestations (5.6%). By means of molecular assays, 8.9% and 1.7% of Zika and Dengue were detected, respectively, in the samples tested. Serological assays for Zika showed 10.6% of samples positive for IgM and 55.8% for IgG. Conclusions: This study provides clinical, epidemiological, and laboratorial profile of Zika virus emergence in high-endemicity setting of dengue.The study relevance is understanding the introduction and concomitant occurrence of a new arbovirus disease.
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Copyright (c) 2024 José Henrique Francisco Roma, Rachel Cruz Alves, Ludiele Souza Castro, Márcio José Ferreira, Claudinéia de Araújo, Bruno Moreira Carneiro, Renata Dezengrini Slhessarenko, Juliana Helena Chavez Pavoni, Mariângela Ribeiro Resende
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