Prevalence of antibodies against HCV and risk behaviors in Basic Health Units users in a small town in the Brazilian semi-arid region
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https://doi.org/10.17058/reci.v15i1.19314Keywords:
Keywords: Hepatitis C Antibody. Hepatitis C. Outpatient. Prevalence. Blood transfusion. Risk behaviors., Descritores: Anticorpo para hepatite C, Hepatite C, Ambulatorial, Prevalência, Transfusão de sangue, Comportamento de risco., Palabras clave: Anticuerpos contra la hepatitis C. Hepatitis C. Paciente externo. Prevalencia. Transfusión de sangre. Conductas de riesgo.Abstract
Background and Objectives: Hepatitis C virus (HCV) infection is a relevant public health problem due to its prevalence and possible progression to cirrhosis and hepatocellular carcinoma. Although the use of direct-acting antivirals has decreased the incidence in recent years, identifying those infected remains a challenge for the elimination of HCV by 2030. The objective of this study was to estimate the prevalence of HCV antibody (anti-HCV), and describe the sociodemographic and behavioral risk factors associated with HCV infection in individuals in a small town in the Brazilian semi-arid region. Methods: Following a non-random sampling procedure, a cross-sectional study of 800 individuals in the waiting rooms of Basic Health Units (BHU) was conducted. After formal consent, a rapid screen test for anti-HCV (Immunochromatography)was carried out, and a questionnaire was applied to collect sociodemographic, clinical and risk behavior data. Results: Five tests were positive (0.62%; 95%CI 0.2 – 1.4%), four women and one man. All were over 60 years old (mean age of 69.4) and some risk behaviors in the past, use of glass syringes, surgery, or blood transfusion, were statistically associated with HCV exposure. Conclusion: In this study, a low prevalence of anti-HCV was observed, close to that estimated in recent studies. The antibody was more frequently positive in older individuals, aged over 60 years, who reported risky past behavior. Greater attention should be given to these individuals.
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Polaris Observatory HCV Collaborators. Global change in Hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study. Lancet Gastroenterol Hepatol 2022; 7(5):396–415.https://doi.org/10.1016/S2468-1253(21)00472-6.
Martinello M, Solomon SS, Terrault NA, et al. Hepatitis C. The Lancet 2023; 402(23): 1085-96.https://doi.org/10.1016/S0140-6736(23)01320-X
Spearman WC, Dusheiko GM, Hellard M, et al. Hepatitis C. The Lancet 2019; 394: 1451–66. https://doi.org/10.1016/S0140-6736(19)32320-7
Benzaken AS, Girade R, Catapan E, et al.Hepatitis C disease burden and strategies for elimination by 2030 in Brazil. A mathematical modeling approach. Braz J Infect Dis 2019;23(3):182-90.https://doi.org/10.1016/j.bjid.2019.04.010
Nascimento MC, Mayaud P, Sabino EC, et al.Prevalence of hepatitis B and C serological markers among first-time blooddonors in Brazil: a multi-center serosurvey.J Med Virol2008; 80:53–7.https://doi.org/10.1002/jmv.21046
Constancio NS, Ferraz MLG, Martins CTB, et al.Hepatitis C in Hemodialysis Units: diagnosis and therapeutic approach. J BrasNefrol 2019; 41(4):539-49. https://doi.org/10.1590/2175-8239-JBN-2018-0177
Puga MAM, Bandeira LM, Pompilio MA, et al.Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil. PLoS One 2017;12(1):e0169195.https://doi.org/10.1371/journal.pone.0169195
Miranda NTGP, Souza RL, Monteiro JC, et al. Seroprevalence of HBV and HCV in female sex workers from four cities in the state of Pará, northern Brazil. J Med Virol 2020; 93: 3730–37. https://doi.org/10.1002/jmv.26759
Niquini RP, Mota JC, Bastos LS, et al.Persistently high hepatitis C rates in haemodialysis patients in Brazil [a systematic review and meta analysis]. Nature 2022; 12:330. https://doi.org/10.1038/s41598-021-03961-x
Focaccia R, da Conceição OJ, Sette JH, et al. Estimated prevalence of viral hepatitis in the general population of the municipality of São Paulo, measured by a serologic survey of a stratified, randomized and residence-based population. Braz J Infect Dis 1998; 2(6):269-84.
Pereira LM, Martelli CM, Moreira RC, et al. BMC Infect Dis 2013;1:13:60. https://doi:10.1186/1471-2334-13-60
WHO. World Health Organization. Combating hepatitis B and C to reach elimination by 2030: advocacy brief. Geneva: World Health Organization; 2016. http://www.who.int/iris/handle/10665/206453
BRASIL. Ministério da Saúde. Plano de eliminação da hepatite C no Brasil [internet]. Brasília: Ministério da Saúde; 2018. 25p. https://www.gov.br/aids/pt-br/centrais-de-conteudo/publicacoes/2019/plano-para-eliminacao-da-hepatite-c-no-brasil/view/
IBGE. The Brazilian Institute of Geography and Statistics: Cities and States [Internet] 2022 [cited: 2023 July 17].https://www.ibge.gov.br/cidades-e-estados/pe/arcoverde.html
Gower, et al. Global epidemiology and genotype distribution of the hepatites C virus infection. J Hepatol 2014; 61: S45-S57.
Almeida D, Tavares-Neto J, Vitvitski L, et al. Serological Markers of Hepatitis A, B and C Viruses in Rural Communities of the Semiarid Brazilian Northeast. Braz J Infect Dis 2006; 10(5):317-21.https://doi.org/10.1590/S1413-86702006000500003
Gardona R, Appel F, Ercolin S, et al. Evaluation of a strategy for identifying hepatitis C virus carriers in outpatient and emergency units: contribution to the microelimination of hepatitis C in Brazil. Braz J Infect Dis 2021;25(2):101546.https://doi.org/10.1016/j.bjid.2021.101546
Neto JR, Cubas MR, Kusma SZ, et al. Prevalence of viral hepatitis C in adult users of Public Health Services in the city of São José dos Pinhais-Paraná. Rev Bras Epidemiol 2012; 15:627-38. https://doi.org/10.1590/S1415-790X2012000300016
Moore KJ, Gauri A, Koru-Sengul T. Prevalence and sociodemographic disparities of Hepatitis C in Baby Boomers and the US adult population. J Infect Public Health 2019; 12(1): 32-6.https://doi.org/10.1016/j.jiph.2018.08.003
Azevedo TCR, Filgueira NA, Lopes EP. Risk factors for hepatitis C virus infection in former Brazilian soccer players. Infect Epidemiol 2012; 10:70-3.https://doi.org/10.1017/S0950268811000458
Gomide GPM, Melo CB, Santos VS, et al. Epidemiological survey of hepatitis C in a region considered of high prevalence: the state of Minas Gerais, Brazil. Rev Soc Bras Med Trop 2019; 52:1-8. https://doi.org/10.1590/0037-8682-0202-2019
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Copyright (c) 2025 Maria Tereza Estevam Vaz Vaz, Norma Arteiro Filgueira Filgueira, Paula Carolina Valença Silva, Alcides da Silva Diniz Diniz, Lílian Rose Maia Gomes de Araújo Araújo, Andrea Batista Dória Dória, Ana Lúcia Coutinho Domingues Domingues, Edmundo Pessoa Lopes Lopes

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