Epidemiological profile of sepsis in a high-complexity hospital in northwest Paraná

Authors

DOI:

https://doi.org/10.17058/reci.v15i1.19482

Keywords:

Epidemiology. Hospitalization. Mortality. Sepsis.

Abstract

Background and Objectives: Sepsis constitutes a major cause of global morbidity and mortality with exorbitant costs. It is necessary to relate the patients’ sociodemographic profile with sepsis diagnosis in order to understand the specific characteristics and outcomes and to provide information for the development of clinical protocols that positively impact prognoses. Methods: This cross-sectional, retrospective, and quantitative study with a documentary research collected data from January to December 2023. Data were analyzed on R (version R-4.3.0) with inferential statistics and association testing. The Fisher’s exact test was used to assess variable relationships, with a 5% significance level. Results: Of the total 320 records, 76.6% (n=245) of patients died and 23.4% (n=75) were discharged. Patients aged over 60 years had a higher risk of infection and unfavorable outcomes. Regarding infection site, death was related to pulmonary (60.4%) and abdominal infections (13.1%). The analysis of the correlation between length of stay and mortality showed a higher incidence of unfavorable outcomes within the first seven days (40.0%). Conclusion: This study showed the relationship between sociodemographic profile and outcomes related to sepsis and septic shock in line with the Brazilian context and adding information that enables the development of a sepsis management protocol to reduce mortality.

Downloads

Download data is not yet available.

Author Biography

Patrícia Junglos, Universidade Estadual de Maringá – UEM. Maringá, Paraná, Brasil.

Enfermeira especialista, modalidade residência, em Urgência e Emergência; Especialista em Controle de Infecções Relacionadas a Assistência em Saúde e Mestranda pelo Programa de Pós-Graduação em Gestão, Tecnologia e Inovação em Urgência e Emergência-PROFURG – UEM.

References

Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sépsis incidence and mortality, 1990–2017: Analysis for the Global Burden of Disease Study. The Lancet [Internet]. janeiro de 2020; 395(10219):200–11. http://dx.doi.org/10.1016/S0140-6736(19)32989-7.

Fuchs A. Sepse: a maior causa de morte nas UTIs [Internet]. [citado 18 de maio de 2024]. https://portal.fiocruz.br/noticia/sepse-maior-causa-de-morte-nas-utis.

ILAS. Instituto Latino-Americano de Sepse. Roteiro de implementação de protocolo assistencial gerenciado de sepse: programa de melhoria de qualidade [Internet]. 2019. Disponível em https://ilas.org.br/assets/arquivos/ferramentas/roteiro-de-implementacao.pdf.

Martischang, R., Pires, D., Masson-Roy, S., Saito, H., & Pittet, D. (2018). Promoting and sustaining a historical and global effort to prevent sepsis: the 2018. World Health Organization SAVE LIVES: Clean Your Hands campaign. Critical care (London, England), 22(1), 92. https://doi.org/10.1186/s13054-018-2011-3.

Rhee, C., Jones, T. M., Hamad, Y., et al. (2019). Prevalence, underlying causes, and preventability of sépsis associated mortality in US acute care hospitals. JAMA network open, 2(2), e187571. https://doi.org/10.1001/jamanetworkopen.2018.7571

Instituto Latino-Americano para Estudos da Sepse. Sepse: UM PROBLEMA DE SAÚDE PÚBLICA. 2016 [citado 18 de maio de 2024]. http://biblioteca.cofen.gov.br/wp-content/uploads/2015/10/livro-um-problema-de-saude-publica.pdf.

Oami T, Imaeda T, Nakada TA, et al. Temporal trends of medical costandcost-effective ness in sepsis patients: a Japanese nation wide medical claimsdatabase. J Intensiv eCare. 2022 Jul 14;10(1):33. https://doi.org/10.1186/s40560-022-00624-5.

Almeida NRC, Pontes GF, Jacob FL, et al. Análise de tendência de mortalidade por sepse no Brasil e por regiões de 2010 a 2019. Rev. Saúde Pública 56 22 Abr 2022. https://doi.org/10.11606/s1518-8787.2022056003789.

Grebenchikov OA, Kuzovlev AN. Long-termoutcomesaftersepsis. Biochemistry. 2021;86(5):563–567. https://doi.org/10.1134/S0006297921050059.

Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence. 11 de janeiro de 2014; 5(1):4–11. Epub 2013 Dec 11. https://doi.org/10.4161/viru.27372.

Olivieri R, Michels M, Pescador B, et al. The aditive effect of agingon sepsis-induced cognitive impairmentand neuro inflammation. J Neuro immunol. janeiro de 2018; 314:1–7. https://doi.org/10.1016/j.jneuroim.2017.11.014.

Lacerda Pedrosa I, Andrade Duarte de Farias M do C, da Silva FA, et al. Characteristics and prognostic fator sofeld Erly patients in intensive care unit. Int Arch Med. 2015. https://doi.org/10.3823/1842.

Lins ANS, Olmedo LE, Ramalho LAG, et al. Perfil epidemiológico das internações por sepse no Brasil entre 2017 e 2021. Research, Society and Development. 4 de setembro de 2022 [citado 4 de maio de 2024]; 11(11):e592111134048. https://rsdjournal.org/index.php/rsd/article/view/34048.

Carvalho M, Silva WNT da, Rosa MFP, et al. Análise epidemiológica das internações por septicemia no Brasil de 2008 A 2019. Em: Saúde em Foco: Temas Contemporâneos - Volume 1 [Internet]. Editora Científica Digital; 2020. p. 273–88. http://www.editoracientifica.com.br/articles/code/200700704.

Garg R, Tellapragada C, Shaw T, et al. Epidemiology of sépsis and risk factors for mortality in intensive care unit: a hospital based prospective study in South India. Infect Dis (Lond). 2022 May;54(5):325-334. Epub 2022 Jan 5. https://doi.org/10.1080/23744235.2021.2017475.

Belo, G.V.; Gaspar, G.L.G.; Lima, L.S. Análise dos Aspectos Epidemiológicos da Sepse e da Potencial Influência da Publicação do Consenso Sepsis-3 na sua Mortalidade no Território Brasileiro. Revista de Saúde. 2020 Jul./Dez.; 11 (2): 44-48. https://doi.org/10.21727/rs.v11i1.2376.

IBGE. Censo demográfico 2022: População e domicílios (primeiros resultados). Brasil. 2023. http://www.ibge.gov.br/estatisticas/sociais/populacao/22827-censo-demografico-2022.html.

Evans L, Rhodes A, Alhazzani W, et al. Surviving sépsis campaign: international guidelines for management of sépsis and septic shock 2021. Intensive Care Med. 2 de novembro de 2021;47(11):1181–247. https://doi.org/10.1007/s00134-021-06506-y.

Volpáti NV, Prado PR do, Maggi LE. Epidemiological profile of patients with abdominal focus sepsis. J Nurs UFPE online. 2019;13:e240403. https://doi.org/10.5205/1981-8963.2019.240403.

Arvaniti K, Dimopoulos G, Antonelli M, et al. Abdominal Sepsis Study (AbSeS) Group on behalf of theTrials Group of the European Society of Intensive Care Medicine. Epidemiology and age-related mortality in critical lyill patients with intra-abdominal infection or sepsis: an international cohort study. Int J Antimicrob Agents. 2022 Jul;60(1):106591. Epub 2022 Apr 20. https://doi.org/10.1016/j.ijantimicag.2022.106591.

Gorordo-Delsol LA, Merinos-Sánchez G, Estrada-Escobar RA, et al. Sepsis and septic shock in emergency departments of Mexico: a multicenter point prevalence study. Gac Med Mex. 2020;156(6):486-492. https://doi.org/10.24875/GMM.M21000492.

Published

2025-01-21

How to Cite

Junglos, P., & Nobuyoshi Kaneshima, E. (2025). Epidemiological profile of sepsis in a high-complexity hospital in northwest Paraná. Revista De Epidemiologia E Controle De Infecção, 15(1). https://doi.org/10.17058/reci.v15i1.19482

Issue

Section

ORIGINAL ARTICLE