Schoolchildren allele carrier a for polymorphism rs9939609 (FTO), present different response to body mass index after interdisciplinary intervention program?

Abstract

Justificative e Objective: Polymorphisms in the gene related to fat mass and obesity - FTO has been associated with obesity by its effects in the individual's energy homeostasis. Thus, we seek to verify if the children with risk allele (A) for obesity polymorphism rs9939609 in the FTO gene, respond differently to an intervention program with physical and nutritional counseling exercise, compared to students who do not have this allele, with relation to body mass index. Methods: A quasi-experimental study with 46 students, distributed also in experimental and control group, the rural municipality of Santa Cruz do Sul-RS. The variant A/T polymorphism rs9939609, the FTO gene was genotyped using the system TaqMan in Step One Plus automated equipment. The interdisciplinary program lasted four months, being held 3 times per week, in turn contrary to the classes. The duration of each session was 1 hour and 30 minutes. Results: In the experimental group, a school with TT genotype were overweight, went on to have a normalBMI after of the program. For AT + AA genotypes, the school kept the score (obesity), and a school who were overweight before the the intervention began to show obesity after termination thereof. The analysis of BMI values before and after the intervention , revealed that there was no significant difference in both the experimental group (p = 0.088) and in the control (p = 0.964). Conclusion: the schoolchildren, regardless of genotype, responded similarly to the interdisciplinary program with exercise and nutritional guidance.