Impact on the clinical evolution of patients with COVID-19 from an Intensive Care Unit with isolation of Candida spp. in respiratory samples

Authors

  • Mariangela Cauz Programa de Residência Farmacêutica em Análises Clínicas, Universidade Estadual do Oeste do Paraná, Hospital Universitário do Oeste do Paraná. Av. Tancredo Neves, 3224 - Bairro Santo Onofre, Cascavel - PR - Brasil. CEP: 85806-470. https://orcid.org/0000-0002-6930-7313
  • Luzia Neri Cosmo Machado Laboratório de Bacteriologia Clínica (LACEPE - Laboratórios de Análises Clínicas de Ensino e Pesquisa), Universidade Estadual do Oeste do Paraná. Hospital Universitário do Oeste do Paraná, Av. Tancredo Neves, 3224 - Bairro Santo Onofre, Cascavel - PR - Brasil. CEP: 85806-470. https://orcid.org/0000-0001-9863-7349
  • Nereida Mello da Rosa Gioppo Laboratório de Bacteriologia Clínica (LACEPE - Laboratórios de Análises Clínicas de Ensino e Pesquisa), Universidade Estadual do Oeste do Paraná. Hospital Universitário do Oeste do Paraná, Av. Tancredo Neves, 3224 - Bairro Santo Onofre, Cascavel - PR - Brasil. CEP: 85806-470. https://orcid.org/0000-0001-6169-0832
  • Suelem Bassan Brandt Laboratório de Análises Clínicas, Setor de Bacteriologia Clínica, Universidade Estadual do Oeste do Paraná. Hospital Universitário do Oeste do Paraná. Av. Tancredo Neves, 3224 - Bairro Santo Onofre, Cascavel - PR - Brasil. CEP: 85806-470. https://orcid.org/0000-0003-1745-7261
  • Edcarlos Augusto Caloi Laboratório de Análises Clínicas, Setor de Bacteriologia Clínica, Universidade Estadual do Oeste do Paraná. Hospital Universitário do Oeste do Paraná. Av. Tancredo Neves, 3224 - Bairro Santo Onofre, Cascavel - PR - Brasil. CEP: 85806-470. https://orcid.org/0000-0001-8737-2779
  • Lilian Cristiane Baeza Laboratório de Microbiologia Experimental, Centro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Rua Universitária, 1619 - Universitário, Cascavel – PR – Brasil. CEP: 85819-110. https://orcid.org/0000-0003-4119-9573

DOI:

https://doi.org/10.17058/reci.v13i4.18245

Keywords:

Covid-19; SARS-CoV-2; Coinfection; Candida; Mechanical ventilation.

Abstract

Background and Objectives: several patients with COVID-19 require hospital admission due to severe respiratory complications and undergo intensive care with mechanical ventilation (MV) support. Associated with this situation, there is an increase in fungal co-infections, which has a negative impact on the outcome of COVID-19. In this regard, this study intended to compare Candida spp. incidence in the respiratory tract of patients admitted in the COVID and General Intensive Care Units (ICU) at a teaching hospital in 2021. Methods: the results of protected tracheal aspirate samples from 556 patients admitted to the COVID ICU and 260 to General ICU as well as the respective records. Results: of the patients analyzed, 38 revealed a positive sample for Candida in the COVID ICU and 10 in the General ICU, with an incidence of 68.3/1000 and 38.5/1000, respectively. Males were predominant in both wards. The most affected age group was the population over 60 years old, and the average hospital admission for the COVID ICU was 22.1 years, and for the General ICU, 24.2. Conclusion: Candida albicans was the most frequently isolated species, and the mortality rate in patients positive for Candida was higher in patients with COVID-19 compared to patients in the General ICU, suggesting that patients infected with SARS-CoV-2, admitted to the ICU under MV, are more predisposed to colonization by Candida spp., which can have a fatal outcome in these patients.

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Published

2023-12-12

How to Cite

Cauz, M., Neri Cosmo Machado, L. ., Mello da Rosa Gioppo, N. ., Bassan Brandt, S. ., Augusto Caloi , E. ., & Cristiane Baeza , L. . (2023). Impact on the clinical evolution of patients with COVID-19 from an Intensive Care Unit with isolation of Candida spp. in respiratory samples. Revista De Epidemiologia E Controle De Infecção, 13(4). https://doi.org/10.17058/reci.v13i4.18245

Issue

Vol. 13 No. 4 (2023)

Section

ORIGINAL ARTICLE

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Copyright (c) 2023 Mariangela Cauz, Luzia Neri Cosmo Machado, Nereida Mello da Rosa Gioppo, Suelem Bassan Brandt, Edcarlos Augusto Caloi , Lilian Cristiane Baeza

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