Antimicrobial prescription and bacterial resistance in a Brazilian Intensive Care Unit

Authors

  • Lucia Collares Meirelles Programa de Pós-Graduação em Assistência Farmacêutica. Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil. https://orcid.org/0000-0002-6906-8615
  • Vera Lúcia Milani Martins Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil https://orcid.org/0000-0002-4769-3049
  • Diogo Pilger Programa de Pós-Graduação em Assistência Farmacêutica. Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil. https://orcid.org/0000-0002-8171-2688

DOI:

https://doi.org/10.17058/reci.v14i1.19024

Keywords:

Anti-Bacterial Agents, Drug Resistance, Microbial, Intensive Care Units, Laboratory Test

Abstract

Background and Objectives: antimicrobial resistance is one of the main public health concerns worldwide. Intensive Care Units have a high prevalence of resistant microorganisms and infections, and the rational use of antibiotics is one of the main strategies for tackling this problem. This work aimed to describe patterns associated with antimicrobial drugs as well as the resistance profile of microorganisms. Methods: an observational study was carried out using data from patients hospitalized in the Intensive Care Unit who used antimicrobial agents. Results: respiratory and cardiological causes were the most frequent reasons for admission, with cephalosporins (29.02%), with penicillin (25.84%) and macrolides (16.10%) being the most used classes of antibiotics. The predominant microorganisms were Klebsiella pneumoniae (13.98%), Staphylococcus aureus (13.44%) and Acinetobacter baumannii (11.83%). Urine cultures and tracheal aspirate were the culture tests with the highest growth of gram-negative microorganisms. Patients with bacteria isolated in tracheal aspirate had longer hospital stays; 20 patients had positive surveillance cultures; and the mortality rate found was 55.45%. Conclusion: the study combined the institution’s epidemiological profile with patient characteristics, isolated microorganisms and outcomes.

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Published

2024-05-14

How to Cite

Collares Meirelles, L., Milani Martins , V. L. ., & Pilger, D. (2024). Antimicrobial prescription and bacterial resistance in a Brazilian Intensive Care Unit. Revista De Epidemiologia E Controle De Infecção, 14(1). https://doi.org/10.17058/reci.v14i1.19024

Issue

Vol. 14 No. 1 (2024)

Section

ORIGINAL ARTICLE

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Copyright (c) 2024 Lucia Collares Meirelles, Vera Lúcia Milani Martins , Diogo Pilger

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