Association of biological factors, social determinants of health, and hospitalization with mortality due to SARS/COVID-19

Authors

DOI:

https://doi.org/10.17058/reci.v14i4.19438

Keywords:

Severe Acute Respiratory Syndrome, Mortality registries, COVID-19 vaccines, Comorbidity, COVID-19 Testing

Abstract

Background and Objectives: To study the factors related to mortality in patients with severe acute respiratory syndrome (SARS) in order to understand the dynamics of transmission, health care delivery, and the epidemiological profile of patients upon the demographic, economic and health care diversity found in Brazil. The present study seeks to evaluate the association of sociodemographic, clinical and hospitalization variables with mortality among hospitalized patients with SARS by COVID-19 between the 14th and 39th epidemiological weeks of 2021 in Ituiutaba-MG. Methods: Cross-sectional study with on-site review of SARS notifications, diagnostic examinations, and death certificates of SARS-CoV-2 cases. Prevalence ratio was estimated using Poisson regression. Results: Out of 8,770 cases confirmed, 592 notifications were evaluated from April 4th to October 2nd, 2021. Fewer years of education, vaccination with two doses and need for invasive ventilation were associated with mortality. The risk of death increased with every year of life (PR=1.03; 95%CI 1.02-1.04), the presence of chronic disease (PR=1.55; 95%CI 1.1-2.18), and ICU hospitalization (PR= 3.49 95%CI 2.7-4.54). Conclusion: In addition to age, pre-existing clinical conditions and ICU hospitalization contribute to mortality.

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Author Biographies

Victor Antonio Ferreira Freire, Universidade Federal de Uberlândia, Programa de Pós-graduação em Ciências da Saúde, Uberlândia, Minas Gerais, Brasil

Biólogo pela Universidade Federal de Uberlândia, mestre em Ciências da Saúde pela Universidade Federal São João del-Rei e doutorando em Ciências da Saúde Universidade Federal de Uberlândia.

Gustavo Siconello dos Santos, Hospital Amaral Carvalho, Jaú, São Paulo, Brasil

Biólogo pela Universidade Federal de Uberlândia, mestre em Genética pela Universidade de São Paulo, residente multiprofissional em Oncologia pela Fundação Amaral Carvalho.

Morun Bernardino Neto, Universidade de São Paulo, Departamento de Ciências Básicas e Ambientais da Escola de Engenharia, Lorena, São Paulo, Brasil.

Biólogo e Odontólogo pela Universidade Federal de Uberlândia, mestre e doutor em Genética e Bioquímica pela Universidade Federal de Uberlândia.

Luciana Karen Calábria, Universidade Federal de Uberlândia, Instituto de Ciências Exatas e Naturais do Pontal, Ituiutaba, Minas Gerais, Brasil

Bióloga pela Universidade Federal de Uberlândia, mestre e doutora em Genética e Bioquímica pela Universidade Federal de Uberlândia.

Alexandre Azenha Alves de Rezende, Universidade Federal de Uberlândia, Instituto de Ciências Exatas e Naturais do Pontal, Ituiutaba, Minas Gerais, Brasil

Biólogo pela Universidade Federal de Uberlândia, mestre e doutor em Genética e Bioquímica pela Universidade Federal de Uberlândia.

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Published

2025-01-07

How to Cite

Ferreira Freire, V. A., Siconello dos Santos, G., Bernardino Neto, M., Karen Calábria, L., & Azenha Alves de Rezende, A. (2025). Association of biological factors, social determinants of health, and hospitalization with mortality due to SARS/COVID-19. Revista De Epidemiologia E Controle De Infecção, 15(1). https://doi.org/10.17058/reci.v14i4.19438

Issue

Vol. 15 No. 1 (2025)

Section

ORIGINAL ARTICLE

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Copyright (c) 2025 Victor Antonio Ferreira Freire, Gustavo Siconello dos Santos, Morun Bernardino Neto, Luciana Calábria, Alexandre Azenha Alves de Rezende

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