Asociación de factores biológicos, determinantes sociales de la salud y hospitalización con mortalidad por SRAS/COVID-19

Autores/as

DOI:

https://doi.org/10.17058/reci.v14i4.19438

Palabras clave:

Síndrome Respiratorio Agudo Grave, Registros de Mortalidad, Vacunas contra la COVID-19, Comorbilidad, Prueba de COVID-19

Resumen

Justificación y Objetivos: Investigar los factores relacionados con la mortalidad en pacientes con el síndrome respiratorio agudo severo (SRAS), a fin de comprender las dinámicas de transmisión, la oferta de servicios sanitarios y el perfil epidemiológico de los pacientes mediante la diversidad de población, económica y de asistencia en salud encontradas en Brasil. El presente estudio busca evaluar la asociación de variables sociodemográficas, clínicas y de hospitalización de individuos con síndrome respiratorio agudo severo por COVID-19 con la mortalidad entre la semana epidemiológica 14 y 39 del año 2021 em Ituiutaba-MG. Métodos: Estudio transversal, con consulta local de notificaciones de SRAS, de diagnóstico y certificado de defunción. Las razones de prevalencia se estimaron mediante regresión de Poisson. Resultados: De los 8.770 casos confirmados, se evaluaron 592 notificaciones entre abril y octubre del 2021. Los menores años de escolaridad, la vacunación con dúas doses, y el uso de ventilación invasiva se asociaron con la muerte. El riesgo de muerte aumentó con cada año de vida (RP=1,03; IC95% 1,02-1,04), en presencia de enfermedad crónica (RP=1,55; IC95% 1,1-2,18), y en pacientes hospitalizados en UCI (RP= 3,49; IC95% 2,7-4,54). Conclusiones: Además de la edad, las condiciones clínicas preexistentes, el ingreso en UCI contribuyen a la muerte.

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Biografía del autor/a

Victor Antonio Ferreira Freire, Universidade Federal de Uberlândia, Programa de Pós-graduação em Ciências da Saúde, Uberlândia, Minas Gerais, Brasil

Biólogo pela Universidade Federal de Uberlândia, mestre em Ciências da Saúde pela Universidade Federal São João del-Rei e doutorando em Ciências da Saúde Universidade Federal de Uberlândia.

Gustavo Siconello dos Santos, Hospital Amaral Carvalho, Jaú, São Paulo, Brasil

Biólogo pela Universidade Federal de Uberlândia, mestre em Genética pela Universidade de São Paulo, residente multiprofissional em Oncologia pela Fundação Amaral Carvalho.

Morun Bernardino Neto, Universidade de São Paulo, Departamento de Ciências Básicas e Ambientais da Escola de Engenharia, Lorena, São Paulo, Brasil.

Biólogo e Odontólogo pela Universidade Federal de Uberlândia, mestre e doutor em Genética e Bioquímica pela Universidade Federal de Uberlândia.

Luciana Karen Calábria, Universidade Federal de Uberlândia, Instituto de Ciências Exatas e Naturais do Pontal, Ituiutaba, Minas Gerais, Brasil

Bióloga pela Universidade Federal de Uberlândia, mestre e doutora em Genética e Bioquímica pela Universidade Federal de Uberlândia.

Alexandre Azenha Alves de Rezende, Universidade Federal de Uberlândia, Instituto de Ciências Exatas e Naturais do Pontal, Ituiutaba, Minas Gerais, Brasil

Biólogo pela Universidade Federal de Uberlândia, mestre e doutor em Genética e Bioquímica pela Universidade Federal de Uberlândia.

Citas

Machhi J, Herskovitz J, Senan AM, et al. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. J Neuroimmune Pharmacol 2020; 15: 359-86. https://doi.org/10.1007%2Fs11481-020-09944-5.

Burki T. COVID-19 in Latin America. Lancet Infect Dis 2020; 20(5):547-548. https://doi.org/10.1016/s1473-3099(20)30303-0.

Brasil. Ministério da Saúde. Painel de casos de doença pelo coronavírus 2019 (COVID-19) no Brasil. [citado 2024 Jan 29]. Disponível em: https://covid.saude.gov.br/.

Brasil. Ministério da Saúde. Ministério da Saúde - Cobertura vacinal - COVID-19. [citado 2024 Jan 29]. Disponível em: https://infoms.saude.gov.br/extensions/SEIDIGI_DEMAS_COBERTURA_COVID_OCORRENCIA/SEIDIGI_DEMAS_COBERTURA_COVID_OCORRENCIA.html.

Santos CVB dos, Noronha TG de, Werneck GL, et al. Estimated COVID-19 severe cases and deaths averted in the first year of the vaccination campaign in Brazil: a retrospective observational study. Lancet Reg Health Am 2023; 17:100418. https://doi.org/10.1016/j.lana.2022.100418.

Brasil. Ministério da Saúde. Estratégia de vacinação contra a COVID-19 - 2024. 1. ed. Brasília: Ministério da Saúde; 2023. 61p. Disponível em: https://infoms.saude.gov.br/content/Default/Informe%20vacinacao%20covid%202024_final_29dez23.pdf.

Zhang JJ, Dong X, Liu GH, et al. Risk and Protective Factors for COVID-19 Morbidity, Severity, and Mortality. Clin Rev Allergy Immunol 2023; 64(1): 90-107. https://doi.org/10.1007/s12016-022-08921-5.

Ayoubkhani D, Khunti K, Nafilyan V, et al. Post-covid syndrome in individuals admitted to hospital with covid-19: Retrospective cohort study. BMJ 2021; 372: n693. https://doi.org/10.1136/bmj.n693.

Li J, Zhou Y, Ma J, et al. The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID. Signal Transduct Target Ther 2023; 8(1): 416. https://doi.org/10.1038/s41392-023-01640-z

Fernandes AT, Rodrigues EK, Araújo ER, et al. Risk factors and survival in patients with COVID-19 in northeastern Brazil. PLoS One 2022; 17(11): e0278213. https://doi.org/10.1371/journal.pone.0278213.

Wang Y, Dong C, Han Y, et al. Immunosenescence, aging and successful aging. Front Immunol 2022; 13: 942796. https://doi.org/10.3389/fimmu.2022.942796.

Zeiser FA, Donida B, André da Costa C, et al. First and second COVID-19 waves in Brazil: A cross-sectional study of patients’ characteristics related to hospitalization and in-hospital mortality. Lancet Reg Health Am 2022; 6: 100107. https://doi.org/10.1016/j.lana.2021.100107.

Colnago M, Benvenuto GA, Casaca W, et al. Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil. Bioengineering 2022; 9(10): 584. https://doi.org/10.3390/bioengineering9100584.

Moura EC, Cortez-Escalante J, Cavalcante FV, et al. Covid-19: temporal evolution and immunization in the three epidemiological waves, Brazil, 2020-2022. Rev Saúde Pública 2022; 56: 105. https://doi.org/10.11606/s1518-8787.2022056004907.

Kerr S, Bedston S, Cezard G, et al. Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales. Lancet 2024; 403: 554-566. https://doi.org/10.1016/S0140-6736(23)02467-4.

Dananché C, Elias C, Hénaff L, et al. Baseline clinical features of COVID-19 patients, delay of hospital admission and clinical outcome: A complex relationship. PLoS One. PLoS One 2022; 17(1): e0261428. https://doi.org/10.1371/journal.pone.0261428.

Thakur B, Dubey P, Benitez J, et al. A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19. Sci Rep 2021; 11: 8592. https://doi.org/10.1038/s41598-021-88130-w.

Kowsar R, Rahimi AM, Sroka M, et al. Risk of mortality in COVID-19 patients: a meta- and network analysis. Sci Rep 2023; 13(1): 2138. https://doi.org/10.1038/s41598-023-29364-8.

Schutte AE, Srinivasapura Venkateshmurthy N, Mohan S, et al. Hypertension in Low- and Middle-Income Countries. Circ Res 2021; 128(7): 808-826. https://doi.org/10.1161/circresaha.120.318729.

Mahamat-Saleh Y, Fiolet T, Rebeaud ME, et al. Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: A systematic review and meta-analysis of observational studies. BMJ Open 2021; 11(10): e052777. https://doi.org/10.1136/bmjopen-2021-052777.

Dessie ZG, Zewotir T. Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients. BMC Infect Dis 2021; 21(1): 855. https://doi.org/10.1186/s12879-021-06536-3.

Alaa A, Qian Z, Rashbass J, et al. Retrospective cohort study of admission timing and mortality following COVID-19 infection in England. BMJ Open 2020; 10(11): e042712. https://doi.org/10.1136/bmjopen-2020-042712.

Scohy A, Anantharajah A, Bodéus M, et al. Low performance of rapid antigen detection test as frontline testing for COVID-19 diagnosis. J Clin Virol. 2020; 129: 104455. https://doi.org/10.1016/j.jcv.2020.104455.

Lima FET, de Albuquerque NLS, Florencio SSG, et al. Time interval between onset of symptoms and COVID-19 testing in Brazilian state capitals, 2020. Epidemiol Serv Saude 2021; 30(1): e2020788. https://doi.org/10.1590/S1679-4974202100010002.

Funk T, Pharris A, Spiteri G, et al. Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021. Euro Surveill 2021; 26(16): 2100348. https://doi.org/10.2807/1560-7917.es.2021.26.16.2100348.

Publicado

2025-01-07

Cómo citar

Ferreira Freire, V. A., Siconello dos Santos, G., Bernardino Neto, M., Karen Calábria, L., & Azenha Alves de Rezende, A. (2025). Asociación de factores biológicos, determinantes sociales de la salud y hospitalización con mortalidad por SRAS/COVID-19. Revista De Epidemiologia E Controle De Infecção, 15(1). https://doi.org/10.17058/reci.v14i4.19438

Número

Vol. 15 Núm. 1 (2025)

Sección

ARTIGO ORIGINAL

Licencia

Derechos de autor 2025 Victor Antonio Ferreira Freire, Gustavo Siconello dos Santos, Morun Bernardino Neto, Luciana Calábria, Alexandre Azenha Alves de Rezende

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